The FUSION Study and Madeline's FUSION-Specific Functionality </head> <body> <center> <h2> The FUSION Study and Madeline's FUSION-Specific Functionality </h2> </center> <p> <center> <table border="1" cellspacing="0" cellpadding="5" width="75%"> <tr> <td bgcolor="#ffffee"> <center> <img src="images/fusion.png"></img> <br><h3>FUSION <br>The Finland-United States Investigation of NIDDM Genetics Study</h3> </center> <p> The aim of the FUSION study is to map and identify susceptibility genes for non-insulin dependent diabetes mellitus (NIDDM) and for the intermediate quantitative traits associated with NIDDM. <p> FUSION individual IDs are eight characters long. The first four characters represent the family ID. This is followed by a dash sign, plus sign or a letter between A-Z. Finally, three unique digits specify individuals within each pedigree. </td> </tr> <tr> <td bgcolor="#eeeeee"> <pre> <b>Sample ID:</b> <b><font color="#0000cc">1021+402</b></font> | | | +-----------------+ | +---------------------+ | | | <b><u>Family ID begins with:</u> <u>Encoded flag symbol:</u> <u>Individual ID:</u></b> - "0" for FUSION 1 "-" for FUSION 1 "100" for probands - "1" for FUSION 2 fam. "+" for FUSION 2 "200" for fathers - "C" for control fam. "A" to "Z" for resampled "300" for mothers - "T" for Trios FUSION records "400" for siblings of the proband (enumerated) "500" for proband spouses (enumerated) "600" for proband offspring (enumerated) "700" for sibling spouses (enumerated) "800" for sibling offspring (enumerated) </pre> </td> </tr> <tr> <td bgcolor="#ffffee"> <p> Madeline is internally aware of the structure of FUSION IDs and uses this information in specific situations to: <p> <ul> <li>Determine family IDs when a family ID field is not provided in the pedigree table.</li> <li>Determine the proband in a sibship when a proband indicator field is not provided in the pedigree table.</li> <li>Insert virtual FUSION parents in a family when only siblings were sampled, <i>even when</i> the father and mother fields contain missing values.</li> <li>Connect spouses to one another even if they have no sampled offspring.</li> <li>Re-connect dummied-in siblings (known via their offspring) to their parents to restore proper pedigree structure when required.</li> </ul> <p> Madeline currently uses the following rules to determine if an ID in a dataset is a FUSION ID: <p> <ul> <li>The ID must be exactly 8 characters long. <li>The <i>first</i> character must be in the set {<b>0,1,C,T,9</b>}. The numeral <b>9</b> is included to support constructed IDs used when part of a larger pedigree is split off for separate analytical treatment. <li>The <i>fifth</i> character must be in the set {<b>-,+,A-Z</b>}. The capital letters <b>A-Z</b> are allowed to support resampled IDs. <li>The <i>sixth</i> character must be in the set {<b>0-9</b>}. <b>0</b> is allowed to support FUSION 1 control "probands" who have a <b>0</b> instead of a <b>1</b> in this position. </ul> <P> A data set can easily contain a mixture of FUSION IDs and non-FUSION IDs. Only IDs meeting the above criteria will be construed as FUSION IDs. </td> </tr> </table> </center> </body> </html>